(19)

(11)

EP 1 071 472 A1

(12)

(43) Date of publication: 31.01.2001 Bulletin 2001/05 (21) Application number: 99919987.0 (22) Date of filing: 23.04.1999

(51) International Patent Classification (IPC)7: A61K 48/00, C12N 15/00, C12N 15/11, C12N 15/63, C12N 15/85, C12N 15/86 (86) International application number: PCT/US9908/884 (87) International publication number: WO 9953/961 (28.10.1999 Gazette 1999/43)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.04.1998 US 65891 (71) Applicant: The Regents of The University of Michigan Technology Management Wolverine Tower Office Ann Arbor,Michigan 48109-1280 (US)	(72) Inventors: BONADIO, Jeffrey, F. Ann Arbor, MI 48108 (US) LABHASETWAR, Vinod, D. Omaha, NE 68164 (US) LEVY, Robert, J. Merion, PA 19066 (US) RICE, Kevin, G. Ann Arbor, MI 48108 (US) (74) Representative: Schüssler, Andrea, Dr.  Kanzlei Huber & SchüsslerTruderinger Strasse 246 81825 München 81825 München (DE)