(19)

(11)

EP 1 071 645 A1

(12)

(43) Date of publication: 31.01.2001 Bulletin 2001/05 (21) Application number: 99919814.6 (22) Date of filing: 13.04.1999

(51) International Patent Classification (IPC)7: C07C 49/23, C07C 49/105, C07C 49/115 (86) International application number: PCT/US9907/995 (87) International publication number: WO 9952/847 (21.10.1999 Gazette 1999/42)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL (30) Priority: 14.04.1998 US 81702 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: CHRISTENSEN, Siegfried, Benjamin, IV Philadelphia, PA 19103 (US) FORSTER, Cornelia, Jutta Pelham, NH 03076 (US) (74) Representative: Rutter, Keith, Dr. et al SmithKline Beecham plcCorporate Intellectual Property,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)