(19)

(11)

EP 1 071 667 A1

(12)

(43) Date of publication: 31.01.2001 Bulletin 2001/05 (21) Application number: 98918154.0 (22) Date of filing: 14.04.1998

(51) International Patent Classification (IPC)7: C07D 223/18, C07C 63/33 (86) International application number: PCT/US9807/389 (87) International publication number: WO 9952/877 (21.10.1999 Gazette 1999/42)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: ROSENBERG, Martin Royersford, PA 19468 (US) WIDDOWSON, Katherine, Louisa King of Prussia, PA 19406 (US) (74) Representative: Valentine, Jill Barbara  SmithKline Beecham plcCorporate Intellectual Property,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)