(19)

(11)

EP 1 071 699 A1

(12)

(43) Date of publication: 31.01.2001 Bulletin 2001/05 (21) Application number: 99917594.6 (22) Date of filing: 15.04.1999

(51) International Patent Classification (IPC)7: C07H 21/04, C12Q 1/68, C12N 15/00, A61K 48/00 (86) International application number: PCT/US9908/434 (87) International publication number: WO 9954/341 (28.10.1999 Gazette 1999/43)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 17.04.1998 US 62416 (71) Applicant: ISIS PHARMACEUTICALS, INC. Carlsbad, CA 92008 (US)	(72) Inventors: BENNETT, C., Frank Carlsbad, CA 92009 (US) CONDON, Thomas, P. Carlsbad, CA 92008 (US) FLOURNOY, Shin, Cheng San Diego, CA 92131 (US) (74) Representative: Hallybone, Huw George et al CARPMAELS AND RANSFORD43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)