(19)

(11)

EP 1 071 708 A1

(12)

(43) Date of publication: 31.01.2001 Bulletin 2001/05 (21) Application number: 99918524.2 (22) Date of filing: 14.04.1999

(51) International Patent Classification (IPC)7: C07K 14/435, C07K 14/47, C07K 14/705, C12N 5/10, C12N 15/85, G01N 33/53, G01N 33/566 (86) International application number: PCT/US9908/099 (87) International publication number: WO 9954/351 (28.10.1999 Gazette 1999/43)

(84) Designated Contracting States: BE CH CY DE DK FR GB IT LI NL (30) Priority: 23.04.1998 US 82776 P 03.09.1998 US 150650 (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: BERGSMA, Derk, J. Berwyn, PA 19312 (US) ELSHOURBAGY, Nabil West Chester, PA 19380 (US) LANE, Pamela Norristown, PA 19401 (US) LI, Xiaotong Devon, PA 19333 (US) MOONEY, Jeffrey, L. Limerick, PA 19468 (US) TSUI, Ping Berwyn, PA 19312 (US) (74) Representative: Crump, Julian Richard John  FJ Cleveland,40-43 Chancery Lane London WC2A 1JQ London WC2A 1JQ (GB)