(19)

(11)

EP 1 071 746 A2

(12)

(88) Date of publication A3: 23.12.1999 (43) Date of publication: 31.01.2001 Bulletin 2001/05 (21) Application number: 99919767.6 (22) Date of filing: 22.04.1999

(51) International Patent Classification (IPC)7: C12N 1/00 (86) International application number: PCT/US9907/016 (87) International publication number: WO 9955/829 (04.11.1999 Gazette 1999/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.04.1998 US 65606 (71) Applicant: Pharmacia & Upjohn S.p.A. 20014 Nerviano (IT)	(72) Inventors: SOLARI, Augusto, Inventi I-20142 Milan (IT) ZANUSO, Giovanna I-20100 Milan (IT) FILIPPINI, Silvia I-20144 Milan (IT) TORTI, Francesca I-20121 Milan (IT) OTTEN, Sharee Madison, WI 53711 (US) COLOMBO, Anna, Luisa I-20144 Milan (IT) HUTCHINSON, Charles, R. Cross Plains, WI 53528 (US)