(19)

(11)

EP 1 071 756 A1

(12)

(43) Date of publication: 31.01.2001 Bulletin 2001/05 (21) Application number: 99916916.2 (22) Date of filing: 06.04.1999

(51) International Patent Classification (IPC)7: C12N 9/24, A01K 67/027, B01D 15/08, C12P 19/00 (86) International application number: PCT/EP9902/475 (87) International publication number: WO 9951/724 (14.10.1999 Gazette 1999/41)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.04.1998 GB 9807464 (71) Applicant: Pharming Intellectual Property BV 2333 CA Leiden (NL)	(72) Inventors: VAN CORVEN, Emile NL-3583 US Utrecht (NL) WEGGEMAN, Miranda NL-2665 DM Bleiswyk (NL) (74) Representative: Williams, Richard Andrew Norman et al Hepworth Lawrence Bryer & BizleyMerlin HouseFalconry CourtBakers Lane Epping, Essex CM16 5DQ Epping, Essex CM16 5DQ (GB)