(19)

(11)

EP 1 071 771 A2

(12)

(88) Date of publication A3: 02.03.2000 (43) Date of publication: 31.01.2001 Bulletin 2001/05 (21) Application number: 99918680.2 (22) Date of filing: 19.04.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C07K 16/18, G01N 33/68, C12Q 1/68, C12N 15/10, C12P 21/00, A61K 48/00 (86) International application number: PCT/US9908/568 (87) International publication number: WO 9954/465 (28.10.1999 Gazette 1999/43)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 20.04.1998 US 82454 P (71) Applicants: WARNER-LAMBERT COMPANY Morris PlainsNew Jersey 07950 (US) UNIVERSITY OF IOWA RESEARCH FOUNDATION Iowa City, IA 52242-5000 (US)	(72) Inventors: MIN, Jing Farmington Hills, MI 48335 (US) PESSIN, Jeffrey, Eugene Iowa City, IA 52246 (US) SALTIEL, Alan, Robert Ann Arbor, MI 48105 (US) SYU, Li-Jyun Canton, MI 48188 (US) (74) Representative: Mansmann, Ivo  Warner-Lambert Company,Legal Division,Legal Department,c/o Gödecke AG 79090 Freiburg 79090 Freiburg (DE)