(19)

(11)

EP 1 071 953 A1

(12)

(43) Date of publication: 31.01.2001 Bulletin 2001/05 (21) Application number: 99918752.9 (22) Date of filing: 21.04.1999

(51) International Patent Classification (IPC)7: G01N 33/53, C12N 5/12, C07K 16/00, C07K 14/00 (86) International application number: PCT/US9908/754 (87) International publication number: WO 9954/733 (28.10.1999 Gazette 1999/43)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.04.1998 US 65647 (71) Applicant: The Regents of the University of California Oakland, CA 94607-5200 (US)	(72) Inventors: DOBBS, Leland, G. Oakland, CA 94611 (US) GONZALEZ, Robert San Francisco, CA 94117 (US) (74) Representative: Goldin, Douglas Michael  J.A. KEMP & CO.14 South SquareGray's Inn London WC1R 5LX London WC1R 5LX (GB)