(19)
(11) EP 1 073 421 A1

(12)

(43) Date of publication:
07.02.2001 Bulletin 2001/06

(21) Application number: 99920064.5

(22) Date of filing: 27.04.1999
(51) International Patent Classification (IPC)7: A61K 9/16, C12N 9/20, C12N 9/04, C12N 9/86
(86) International application number:
PCT/US9909/099
(87) International publication number:
WO 9955/310 (04.11.1999 Gazette 1999/44)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 27.04.1998 US 83148 P
31.12.1998 US 224475

(71) Applicant: Altus Biologics Inc.
Cambridge, MA 02139-4211 (US)

(72) Inventors:
  • MARGOLIN, Alexey, L.
    Newton, MA 02161 (US)
  • KHALAF, Nazer, K.
    Worcester, MA 01602 (US)
  • ST. CLAIR, Nancy, L.
    Durham, NC 27707 (US)
  • RAKESTRAW, Scott, L.
    Newark, DE 19711-2826 (US)
  • SHENOY, Bhami, C.
    Woburn, MA 01801 (US)

(74) Representative: VOSSIUS & PARTNER 
Siebertstrasse 4
81675 München
81675 München (DE)

   


(54) STABILIZED PROTEIN CRYSTALS, FORMULATIONS CONTAINING THEM AND METHODS OF MAKING THEM