(19)

(11)

EP 1 073 425 A1

(12)

(43) Date of publication: 07.02.2001 Bulletin 2001/06 (21) Application number: 99921733.4 (22) Date of filing: 28.04.1999

(51) International Patent Classification (IPC)7: A61K 9/50, A61K 9/16 (86) International application number: PCT/US9909/940 (87) International publication number: WO 9955/314 (04.11.1999 Gazette 1999/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 30.04.1998 US 83709 P (71) Applicant: THE UNIVERSITY OF CINCINNATI Cincinnati, OH 45267-0829 (US)	(72) Inventors: RETZINGER, Gregory, S. Cincinnati, OH 45140 (US) DEANGLIS, Ashley, P. Cincinnati, OH 45220 (US) (74) Representative: Müller-Boré & PartnerPatentanwälte  Grafinger Strasse 2 81671 München 81671 München (DE)