(19)
(11) EP 1 073 633 A2

(12)

(88) Date of publication A3:
27.07.2000

(43) Date of publication:
07.02.2001 Bulletin 2001/06

(21) Application number: 99921611.2

(22) Date of filing: 30.04.1999
(51) International Patent Classification (IPC)7: C07C 323/60, A61K 31/16, C07C 237/14, C07C 237/12, C07C 311/19, C07C 235/16, C07D 295/185
(86) International application number:
PCT/US9909/641
(87) International publication number:
WO 9957/098 (11.11.1999 Gazette 1999/45)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
Designated Extension States:
RO SI

(30) Priority: 01.05.1998 US 71714

(71) Applicant: ABBOTT LABORATORIES
Abbott Park,IL 60064-6050 (US)

(72) Inventors:
  • CRAIG, Richard, A.
    Racine, WI 53404 (US)
  • HENKIN, Jack
    Highland Park, IL 60035 (US)
  • KAWAI, Megumi
    Libertyville, IL 60048 (US)
  • LYNCH, Linda, Lijewski
    Pleasant Prairie, WI 53158 (US)
  • PATEL, Jyoti
    Libertyville, IL 60048 (US)
  • SHEPPARD, George, S.
    Wilmette, IL 60091 (US)
  • WANG, Jieyi
    Gurnee, IL 60031 (US)

(74) Representative: Modiano, Guido, Dr.-Ing. et al
Modiano, Josif, Pisanty & Staub,Baaderstrasse 3
80469 München
80469 München (DE)

   


(54) SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2