(19)

(11)

EP 1 073 671 A1

(12)

(43) Date of publication: 07.02.2001 Bulletin 2001/06 (21) Application number: 99919789.0 (22) Date of filing: 23.04.1999

(51) International Patent Classification (IPC)7: C07H 21/04, C12N 7/00, C12N 7/04, C12N 15/63 (86) International application number: PCT/US9907/398 (87) International publication number: WO 9955/720 (04.11.1999 Gazette 1999/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.04.1998 US 82953 P 12.02.1999 US 249402 (71) Applicant: The Regents of the University of California Oakland, CA 94607-5200 (US)	(72) Inventors: MARKS, James, D. Kensington, CA 94707 (US) POUL, Marie, Alix F-34160 Castries (FR) BECERRIL, Baltazar Morelos 62210 (MX) (74) Representative: Brasnett, Adrian Hugh et al Mewburn EllisYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)