(19)

(11)

EP 1 073 677 A1

(12)

(43) Date of publication: 07.02.2001 Bulletin 2001/06 (21) Application number: 99918764.4 (22) Date of filing: 22.04.1999

(51) International Patent Classification (IPC)7: C07K 14/31, C12N 1/21, C12N 9/12, C12N 15/31, C12N 15/52, C12N 15/63, G01N 33/53 (86) International application number: PCT/US9908/785 (87) International publication number: WO 9955/729 (04.11.1999 Gazette 1999/44)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (30) Priority: 27.04.1998 US 66922 (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: PETIT, Chantal, Myriam Wayne, PA 19087 (US) WARREN, Richard, L. Blue Bell, PA 19424 (US) TRAINI, Christopher, M. Media, PA 19063 (US) WANG, Min Blue Bell, PA 19422 (US) (74) Representative: Mallalieu, Catherine Louise  D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)