(19)

(11)

EP 1 073 746 A2

(12)

(88) Date of publication A3: 23.03.2000 (43) Date of publication: 07.02.2001 Bulletin 2001/06 (21) Application number: 99920711.1 (22) Date of filing: 20.04.1999

(51) International Patent Classification (IPC)7: C12N 15/31, C07K 14/195, C07K 14/395, C12Q 1/68, G01N 33/50 (86) International application number: PCT/EP9902/636 (87) International publication number: WO 9954/473 (28.10.1999 Gazette 1999/43)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 22.04.1998 GB 9808366 (71) Applicant: GLAXO GROUP LIMITED Greenford, Middlesex UB6 ONN (GB)	(72) Inventors: ARIGONI, Fabrizio CH-1204 Geneva (CH) EDGERTON, Michael David Mystic, CT 06355 (US) LOFERER, Hannes D-82538 Geretsried (DE) PEITSCH, Manuel, C. CH-1855 La Forclaz (CH) (74) Representative: Rees, Marion Lindsay et al Glaxo Wellcome plc,Glaxo Wellcome House,Intellectual Property Department,Berkeley Avenue Greenford,Middlesex UB6 0NN Greenford,Middlesex UB6 0NN (GB)