NOVEL SERINE PROTEASE CAPABLE OF SELECTIVE CLEAVAGE OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN - Patent 1073755

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EP 1 073 755 A2

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(88)	Date of publication A3:
	24.02.2000

(43)	Date of publication:
	07.02.2001 Bulletin 2001/06

(21)	Application number: 99918882.4

(22)	Date of filing: 28.04.1999

(51)	International Patent Classification (IPC)⁷: C12N 15/57, C12N 9/64, C12N 5/10, C12N 1/21, C12N 15/62, C07K 16/40, C12P 21/06, C12Q 1/37

(86)	International application number:
	PCT/US9909/224

(87)	International publication number:
	WO 9955/885 (04.11.1999 Gazette 1999/44)

(84)	Designated Contracting States:
	AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
	Designated Extension States:
	AL LT LV MK RO SI

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Priority:

28.04.1998 US 83321 P

(71)	Applicant: AXYS PHARMACEUTICALS, INC.
	South San Francisco, CA 94080 (US)

(72)	Inventors:
	SMEEKENS, Steven, P. Danville, CA 94529 (US) HOU, Jinzhao South San Francisco, CA 94080 (US)

(74)	Representative: Brasnett, Adrian Hugh et al
	Mewburn EllisYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)

(54)	NOVEL SERINE PROTEASE CAPABLE OF SELECTIVE CLEAVAGE OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN