(19)

(11)

EP 1 073 758 A1

(12)

(43) Date of publication: 07.02.2001 Bulletin 2001/06 (21) Application number: 99914700.2 (22) Date of filing: 28.04.1999

(51) International Patent Classification (IPC)7: C12N 15/86, C12N 15/48, C12N 15/62, C07K 14/15, C07K 19/00, A61K 48/00 (86) International application number: PCT/IB9900/764 (87) International publication number: WO 9955/893 (04.11.1999 Gazette 1999/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 29.04.1998 US 69398 (71) Applicant: THE UNIVERSITY OF SOUTHERN CALIFORNIA Los Angeles,California 90089 (US)	(72) Inventors: HALL, Frederick, L. Glendale, CA 91203 (US) GORDON, Erlinda, Maria Glendale, CA 91203 (US) ANDERSON, W., French San Marino, CA 91108 (US) (74) Representative: Becker, Konrad et al Novartis AGCorporate Intellectual PropertyPatent- und Markenabteilung 4002 Basel 4002 Basel (CH)