(19)

(11)

EP 1 073 765 A2

(12)

(88) Date of publication A3: 16.03.2000 (43) Date of publication: 07.02.2001 Bulletin 2001/06 (21) Application number: 99917716.5 (22) Date of filing: 26.04.1999

(51) International Patent Classification (IPC)7: C12Q 1/68 (86) International application number: PCT/CA9900/377 (87) International publication number: WO 9955/906 (04.11.1999 Gazette 1999/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 27.04.1998 US 83077 P (71) Applicant: University Health Network Toronto,Ontario M5G 2M9 (CA)	(72) Inventors: WOODGETT, James, R. Don Mills, Ontario M3A 2A7 (CA) MANOUKIAN, Armen, S. North York, Ontario M3C 2E6 (CA) JIN, Jing Toronto,Ontario M4Y 1R5 (CA) WETSCH, Ben Toronto, Ontario M5R 2R8 (CA) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)