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(11)

EP 1 074 625 A3

(12)	EUROPEAN PATENT APPLICATION

(88) Date of publication A3: 02.01.2002 Bulletin 2002/01 (43) Date of publication A2: 07.02.2001 Bulletin 2001/06 (21) Application number: 00304924.4 (22) Date of filing: 09.06.2000

(51) International Patent Classification (IPC)7: C12N 15/49, A61K 39/21, A61K 48/00, C07K 16/10, A61P 31/14 // C07K14/155

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 14.06.1999 US 138999 P (71) Applicant: Pfizer Products Inc. Groton, Connecticut 06340 (US)

(72) Inventors: Deng, Ruitang Groton, Connecticut 06340 (US) Jeevarathnam, Suresh Groton, Connecticut 06340 (US) Fuog, Eric Douglas Groton, Connecticut 06340 (US) Koertje, William Dee Groton, Connecticut 06340 (US) Johnson, Anthony Fay Groton, Connecticut 06340 (US) Sheppard, Michael George Groton, Connecticut 06340 (US) Yule, Terecita Dolores Groton, Connecticut 06340 (US) Roth, Mark Brian Groton, Connecticut 06340 (US) Wheeler, David Walter Groton, Connecticut 06340 (US) (74) Representative: Simpson, Alison Elizabeth Fraser et al Urquhart-Dykes & Lord, 30 Welbeck Street London W1G 8ER London W1G 8ER (GB)