(19)

(11)

EP 1 075 524 A2

(12)

(88) Date of publication A3: 29.12.1999 (43) Date of publication: 14.02.2001 Bulletin 2001/07 (21) Application number: 99919444.2 (22) Date of filing: 06.05.1999

(51) International Patent Classification (IPC)7: C12N 15/44, C12N 7/01, C12N 15/86, A61K 39/145 (86) International application number: PCT/GB9901/413 (87) International publication number: WO 9957/284 (11.11.1999 Gazette 1999/45)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.05.1998 GB 9809666 (71) Applicant: ISIS INNOVATION LIMITED Summertown,Oxford OX2 7BZ (GB)	(72) Inventors: BROWNLEE, George, Gow Oxford OX1 3RE (GB) FODOR, Ervin Oxford OX1 3RE (GB) PALESE, PeterMount Sinai School of Medicine New York, NY 10029 (US) GARC A-SASTRE, AdolfoMount Sinai School of Medic. New York, NY 10029 (US) (74) Representative: Irvine, Jonquil Claire et al J.A. KEMP & CO.14 South SquareGray's Inn London WC1R 5LX London WC1R 5LX (GB)