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(11)

EP 1 075 532 A1

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(43) Date of publication: 14.02.2001 Bulletin 2001/07 (21) Application number: 99921601.3 (22) Date of filing: 30.04.1999

(51) International Patent Classification (IPC)7: C12N 15/86, C12N 5/10 (86) International application number: PCT/US9909/590 (87) International publication number: WO 9957/296 (11.11.1999 Gazette 1999/45)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 01.05.1998 US 83841 P 01.02.1999 US 118118 P (71) Applicant: GENZYME CORPORATION Framingham,Massachusetts 01701 (US)	(72) Inventors: WADSWORTH, Samuel, C. Shrewsbury, MA 01545 (US) SCARIA, Abraham Framingham, MA 01701 (US) (74) Representative: Frohwitter, Bernhard, Dipl.-Ing. et al Patent- und Rechtsanwälte,Possartstrasse 20 81679 München 81679 München (DE)