(19)

(11)

EP 1 076 567 A1

(12)

(43) Date of publication: 21.02.2001 Bulletin 2001/08 (21) Application number: 99924234.0 (22) Date of filing: 14.05.1999

(51) International Patent Classification (IPC)7: A61K 39/00, A61K 39/38, A61K 39/02, A61K 39/10, A61K 39/102, A61K 39/108, A01N 63/00, C12N 1/00, C12N 1/36 (86) International application number: PCT/US9910/650 (87) International publication number: WO 9959/626 (25.11.1999 Gazette 1999/47)

(84) Designated Contracting States: DE FR GB IT (30) Priority: 15.05.1998 US 85634 P (71) Applicant: Mkb Investments Limited Partnership Spicer, MN 56288 (US)	(72) Inventor: BRINTON, Marshall, K. Spicer, MN 56288 (US) (74) Representative: Hubert, Philippe et al Cabinet Beau de Loménie158, rue de l'Université 75340 Paris Cédex 07 75340 Paris Cédex 07 (FR)