(19)
(11) EP 1 076 641 A1

(12)

(43) Date of publication:
21.02.2001 Bulletin 2001/08

(21) Application number: 99918831.1

(22) Date of filing: 26.04.1999
(51) International Patent Classification (IPC)7: C07C 235/56, C07C 217/84, C07D 263/32, C07C 311/21, A61K 31/165, A61K 31/135, A61K 31/18, A61K 31/395
(86) International application number:
PCT/US9909/005
(87) International publication number:
WO 9955/663 (04.11.1999 Gazette 1999/44)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 29.04.1998 US 83385 P

(71) Applicant: VERTEX PHARMACEUTICALS INCORPORATED
Cambridge, MA 02139-4242 (US)

(72) Inventors:
  • SAUNDERS, Jeffrey
    Acton, MA 01720 (US)
  • ELBAUM, Daniel
    Newton, MA 02462 (US)
  • NOVAK, Perry
    Milford, MA 01757 (US)
  • NAEGELE, Douglas
    Washington, DC 20037 (US)
  • BETHIEL, Scott
    Bedford, MA 01730 (US)
  • RONKIN, Steven
    Watertown, MA 02472 (US)
  • BADIA, Michael
    Bedford, MA 01730 (US)
  • FRANK, Catharine
    Langhorne, PA 19053 (US)
  • STAMOS, Dean
    Framingham, MA 01701 (US)
  • WALTERS, William
    Waltham, MA 02154 (US)
  • PEARLMAN, David
    Arlington, MA 02476 (US)

(74) Representative: VOSSIUS & PARTNER 
Siebertstrasse 4
81675 München
81675 München (DE)

   


(54) INHIBITORS OF IMPDH ENZYME