(19)

(11)

EP 1 076 698 A2

(12)

(88) Date of publication A3: 06.04.2000 (43) Date of publication: 21.02.2001 Bulletin 2001/08 (21) Application number: 99921969.4 (22) Date of filing: 14.05.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/82, A01H 5/00, A61K 38/36 (86) International application number: PCT/US9910/732 (87) International publication number: WO 9958/699 (18.11.1999 Gazette 1999/46)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 14.05.1998 US 80003 06.05.1999 US 306847 (71) Applicant: BATTELLE MEMORIAL INSTITUTE Richland, WA 99352 (US)	(72) Inventors: HOOKER, Brian, S. Kennewick, WA 99336 (US) GAO, Jianwei Richland, WA 99352 (US) ANDERSON, Daniel, B. Pasco, WA 99301 (US) DAI, Ziyu Richland, WA 99352 (US) (74) Representative: Plougmann, Vingtoft & Partners A/S  Sankt Annae Plads 11,P.O. Box 3007 1021 Copenhagen K 1021 Copenhagen K (DK)