(19)

(11)

EP 1 076 717 A1

(12)

(43) Date of publication: 21.02.2001 Bulletin 2001/08 (21) Application number: 99921724.3 (22) Date of filing: 07.05.1999

(51) International Patent Classification (IPC)7: C12P 21/02, C12N 15/63, C12N 1/21, A61K 31/715 (86) International application number: PCT/US9909/914 (87) International publication number: WO 9958/705 (18.11.1999 Gazette 1999/46)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 08.05.1998 US 84705 P (71) Applicant: AMERICAN CYANAMID COMPANY Madison, New Jersey 07940 (US)	(72) Inventors: BRENNAN, Lynn, A. Pennington, NJ 08534 (US) DIERKS, Peter, M. Yardley, PA 19067 (US) MCINTOSH, Arthur Columbia, MO 65203 (US) (74) Representative: Köster, Reinhold  BASF Aktiengesellschaft 67056 Ludwigshafen 67056 Ludwigshafen (DE)