(19)

(11)

EP 1 077 704 A1

(12)

(43) Date of publication: 28.02.2001 Bulletin 2001/09 (21) Application number: 99921795.3 (22) Date of filing: 10.05.1999

(51) International Patent Classification (IPC)7: A61K 31/55, A61K 31/44, A61K 31/415, A61K 31/445, A61K 31/34, A61K 31/15, A61K 31/135 (86) International application number: PCT/US9910/092 (87) International publication number: WO 9959/593 (25.11.1999 Gazette 1999/47)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV RO SI (30) Priority: 21.05.1998 US 86268 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)	(72) Inventors: MICHELSON, David . Carmel, IN 46032 (US) TOLLEFSON, Gary, Dennis Indianapolis, IN 46236 (US) (74) Representative: Vaughan, Jennifer Ann et al Lilly Research Centre,Erl Wood Manor Windlesham,Surrey GU20 6PH Windlesham,Surrey GU20 6PH (GB)