(19)

(11)

EP 1 077 958 A1

(12)

(43) Date of publication: 28.02.2001 Bulletin 2001/09 (21) Application number: 99924163.1 (22) Date of filing: 10.05.1999

(51) International Patent Classification (IPC)7: C07D 263/32, C07D 413/10, C07D 413/12, C07D 277/24, C07D 417/12, A61K 31/42, A61K 31/425, C07D 413/04, C07D 417/04 (86) International application number: PCT/US9910/183 (87) International publication number: WO 9958/511 (18.11.1999 Gazette 1999/46)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV RO SI (30) Priority: 12.05.1998 US 76710 (71) Applicant: AMERICAN HOME PRODUCTS CORPORATION Madison, New Jersey 07940-0874 (US)	(72) Inventor: MALAMAS, Michael, Sotirios Jamison, PA 18929 (US) (74) Representative: Walters, Philip Bernard William et al Wyeth Laboratories,Patents & Trade Marks Department,Huntercombe Lane South,Taplow Maidenhead,Berkshire SL6 0PH Maidenhead,Berkshire SL6 0PH (GB)