(19)

(11)

EP 1 078 048 A2

(12)

(88) Date of publication A3: 03.02.2000 (43) Date of publication: 28.02.2001 Bulletin 2001/09 (21) Application number: 99924251.4 (22) Date of filing: 14.05.1999

(51) International Patent Classification (IPC)7: C12N 15/00, A01K 67/027, C12N 15/90, A61K 48/00, C07K 14/47, C12N 9/10 (86) International application number: PCT/US9910/731 (87) International publication number: WO 9960/108 (25.11.1999 Gazette 1999/47)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 15.05.1998 US 79877 (71) Applicant: SRI INTERNATIONAL Menlo Park,California 94025-3493 (US)	(72) Inventors: PATI, Sushma Redwood City, CA 94061 (US) ZARLING, David Menlo Park, CA 94025 (US) (74) Representative: Baldock, Sharon Claire et al BOULT WADE TENNANT,Verulam Gardens70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)