(19)

(11)

EP 1 078 099 A1

(12)

(43) Date of publication: 28.02.2001 Bulletin 2001/09 (21) Application number: 99917315.6 (22) Date of filing: 19.04.1999

(51) International Patent Classification (IPC)7: C12Q 1/68, C12P 19/34, A61K 39/395, A61K 38/02 (86) International application number: PCT/US9906/537 (87) International publication number: WO 9955/911 (04.11.1999 Gazette 1999/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.04.1998 US 83046 P (71) Applicant: Fang, Fang San Diego, CA 92121 (US)	(72) Inventor: Fang, Fang San Diego, CA 92121 (US) (74) Representative: Baldock, Sharon Claire et al BOULT WADE TENNANT,Verulam Gardens70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)