(19)

(11)

EP 1 079 821 A1

(12)

(43) Date of publication: 07.03.2001 Bulletin 2001/10 (21) Application number: 98943273.7 (22) Date of filing: 20.08.1998

(51) International Patent Classification (IPC)7: A61K 31/175, A61K 31/34, A61K 31/38, A61K 31/41, A61K 31/42, A61K 31/425, A61K 31/44, A61K 31/47, A61K 31/535, C07C 281/06, C07D 213/54, C07D 217/16, C07D 263/32, C07D 265/30, C07D 277/64, C07D 307/81, C07D 413/04, C07D 495/04 (86) International application number: PCT/US9817/275 (87) International publication number: WO 9959/570 (25.11.1999 Gazette 1999/47)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL (30) Priority: 21.05.1998 US 86553 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: HALBERT, Stacie, Marie Harleysville, PA 19438 (US) THOMPSON, Scott, Kevin Phoenixville, PA 19460 (US) VEBER, Daniel, Frank Ambler, PA 19002 (US) (74) Representative: Rutter, Keith, Dr. et al SmithKline Beecham plcCorporate Intellectual Property,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)