(19)

(11)

EP 1 079 861 A1

(12)

(43) Date of publication: 07.03.2001 Bulletin 2001/10 (21) Application number: 99920038.9 (22) Date of filing: 27.04.1999

(51) International Patent Classification (IPC)7: A61K 39/395, A61K 39/00, A61K 39/38, A61K 39/02, A61K 39/108, C12Q 1/00, C12N 9/00, C07H 21/02, C07H 21/04 (86) International application number: PCT/US9909/034 (87) International publication number: WO 9955/368 (04.11.1999 Gazette 1999/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 27.04.1998 US 83259 P 02.10.1998 US 102870 P (71) Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE CambridgeMassachusetts 02138 (US)	(72) Inventors: O'TOOLE, George, A. Boston, MA 02115 (US) KOLTER, Roberto Chestnut Hill, MA 02167 (US) PRATT, Leslie Brookline, MA 02446 (US) (74) Representative: Davies, Jonathan Mark  Reddie & Grose16 Theobalds Road London WC1X 8PL London WC1X 8PL (GB)