(19)
(11) EP 1 080 066 A1

(12)

(43) Date of publication:
07.03.2001 Bulletin 2001/10

(21) Application number: 99924405.6

(22) Date of filing: 20.05.1999
(51) International Patent Classification (IPC)7: C07C 229/60
(86) International application number:
PCT/US9911/199
(87) International publication number:
WO 9961/409 (02.12.1999 Gazette 1999/48)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 22.05.1998 US 83652
22.05.1998 US 86429 P

(71) Applicant: Shionogi Bioresearch Corporation
Lexington, MA 02173 (US)

(72) Inventors:
  • ONO, Mitsunori
    Lexington, MA 02420 (US)
  • KOYA, Keizo
    Brookline, MA 02146 (US)
  • SUN, Lijun
    Decatur, AL 35603 (US)
  • WADA, Yumiko
    Waltham, MA 02154 (US)
  • WRONA, Wojciech
    Brookline, MA 02146 (US)
  • DALES, Natalie
    Arlington, MA 02174 (US)
  • TAO, Xueliang
    Arlington, MA 02174 (US)
  • HOLDEN, Sylvia
    Woburn, MA 01801 (US)

(74) Representative: Behnisch, Werner, Dr. 
Reinhard-Skuhra-WeiseFriedrichstrasse 31
80801 München
80801 München (DE)

   


(54) BIOREDUCTIVE CYTOTOXIC AGENTS