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EP 1 080 106 A1

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(43) Date of publication: 07.03.2001 Bulletin 2001/10 (21) Application number: 99925654.8 (22) Date of filing: 17.05.1999

(51) International Patent Classification (IPC)7: C07K 14/00, C07K 7/00, C12N 5/10, C12N 15/11, C12N 15/12, C12N 15/63 (86) International application number: PCT/US9910/915 (87) International publication number: WO 9960/020 (25.11.1999 Gazette 1999/47)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 18.05.1998 US 80478 20.10.1998 US 175928 (71) Applicant: GENETICS INSTITUTE, INC. Cambridge,Massachusetts 02140 (US)

(72) Inventors: JACOBS, Kenneth Newton, MA 02160 (US) McCOY, John, M. Reading, MA 01867 (US) LaVALLIE, Edward, R. Harvard, MA 01451 (US) COLLINS-RACIE, Lisa, A. Acton, MA 01720 (US) EVANS, Cheryl Germantown, MD 20874 (US) MERBERG, David Acton, MA 01720 (US) MI, Sha Belmont, MA 02178 (US) TREACY, Maurice Dublin 18 (IE) (74) Representative: Frohwitter, Bernhard, Dipl.-Ing. et al Patent- und Rechtsanwälte,Possartstrasse 20 81679 München 81679 München (DE)