(19)

(11)

EP 1 082 122 A1

(12)

(43) Date of publication: 14.03.2001 Bulletin 2001/11 (21) Application number: 99925828.8 (22) Date of filing: 25.05.1999

(51) International Patent Classification (IPC)7: A61K 31/55, A61K 31/12 (86) International application number: PCT/US9911/532 (87) International publication number: WO 9961/028 (02.12.1999 Gazette 1999/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 27.05.1998 US 85480 (71) Applicant: Gorbach, Sherwood L. Weston, MA 02193 (US)	(72) Inventors: GORBACH, Sherwood, L. Weston, MA 02193 (US) GOLDIN, Barry, R. Newton, MA 02465 (US) (74) Representative: Grund, Martin, Dr. et al Holbeinstrasse 5 81679 München 81679 München (DE)