(19)

(11)

EP 1 082 320 A1

(12)

(43) Date of publication: 14.03.2001 Bulletin 2001/11 (21) Application number: 99924480.9 (22) Date of filing: 25.05.1999

(51) International Patent Classification (IPC)7: C07D 403/14, C07D 413/14, A61K 31/505, A61K 31/535 (86) International application number: PCT/US9911/455 (87) International publication number: WO 9961/440 (02.12.1999 Gazette 1999/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 26.05.1998 US 86645 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventor: ADAMS, Jerry, Leroy Wayne, PA 19087 (US) (74) Representative: Blakey, Alison Jane et al Smithkline Beecham,Corporate Intellectual Property,Two New Horizons Court Brentford,Middlesex, TW8 9EP Brentford,Middlesex, TW8 9EP (GB)