(19)

(11)

EP 1 082 425 A2

(12)

(88) Date of publication A3: 27.01.2000 (43) Date of publication: 14.03.2001 Bulletin 2001/11 (21) Application number: 99925184.6 (22) Date of filing: 03.06.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/705, C12Q 1/68, C12N 15/85, C12N 5/10, A61K 48/00, A01K 67/027 (86) International application number: PCT/GB9901/743 (87) International publication number: WO 9963/081 (09.12.1999 Gazette 1999/49)

(84) Designated Contracting States: CH DE FR GB IT LI SE (30) Priority: 03.06.1998 GB 9811965 (71) Applicant: UNIVERSITY COLLEGE LONDON London WC1E 6HA (GB)	(72) Inventors: WOOD, John, NicholasUniversity College London London WC1E 6BT (GB) ENGLAND, Steven SandwichKent CT13 9NJ (GB) CHEN, Chih, Cheng Bethesda, MD 20892 (US) AKOPIAN, Armen NorakovitchUniv. Coll. London Lo ndon WC1E 6BT (GB) (74) Representative: Kremer, Simon Mark et al Mewburn Ellis,York House,23 Kingsway London WC2B 6HP London WC2B 6HP (GB)