(19)

(11)

EP 1 082 441 A1

(12)

(43) Date of publication: 14.03.2001 Bulletin 2001/11 (21) Application number: 99925163.0 (22) Date of filing: 27.05.1999

(51) International Patent Classification (IPC)7: C12N 15/54, C12N 9/10, C07K 16/40, G01N 33/68, C12Q 1/48, G01N 33/53, C12Q 1/68, A61K 35/00 (86) International application number: PCT/GB9901/692 (87) International publication number: WO 9961/625 (02.12.1999 Gazette 1999/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 27.05.1998 GB 9811407 (71) Applicant: ISIS INNOVATIONS LIMITED Oxford,Oxfordshire OX1 3UB (GB)	(72) Inventors: SIM, Edith Kidlington,Oxfordshire OX5 2PR (GB) PAYTON, Mark Oxford,Oxfordshire OX2 0BE (GB) SINCLAIR, John York,Yorkshire YO3 7BH (GB) (74) Representative: Heaton, Joanne Marie et al Stevens, Hewlett & Perkins 1 St. Augustine's Place Bristol BS1 4UD Bristol BS1 4UD (GB)