(19)

(11)

EP 1 083 909 A1

(12)

(43) Date of publication: 21.03.2001 Bulletin 2001/12 (21) Application number: 99928361.7 (22) Date of filing: 01.06.1999

(51) International Patent Classification (IPC)7: A61K 35/12, A61K 38/16, C12N 15/11, C12N 15/12, C12N 15/00, C12N 1/00, C07K 16/00, C12Q 1/68, G01N 33/68, C12P 21/02 (86) International application number: PCT/US9912/125 (87) International publication number: WO 9964/021 (16.12.1999 Gazette 1999/50)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (30) Priority: 11.06.1998 US 95734 (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: ELSHOURBAGY, Nabil, A. West Chester, PA 19380 (US) LI, Xiaotong Devon, PA 19333 (US) (74) Representative: Crump, Julian Richard John  FJ Cleveland,40-43 Chancery Lane London WC2A 1JQ London WC2A 1JQ (GB)