(19)

(11)

EP 1 083 982 A1

(12)

(43) Date of publication: 21.03.2001 Bulletin 2001/12 (21) Application number: 99927131.5 (22) Date of filing: 01.06.1999

(51) International Patent Classification (IPC)7: B01F 3/04, B01F 7/26, A61M 16/14 (86) International application number: PCT/US9912/132 (87) International publication number: WO 9962/626 (09.12.1999 Gazette 1999/49)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 01.06.1998 US 87530 P (71) Applicant: ALLIANCE PHARMACEUTICAL CORPORATION San DiegoCalifornia 92121 (US)	(72) Inventor: NUGENT, Lawrence, J. San Diego, CA 92122 (US) (74) Representative: Coles, Graham Frederick  Graham Coles & Co.24 Seeleys Road BeaconsfieldBuckinghamshire HP9 1SZ BeaconsfieldBuckinghamshire HP9 1SZ (GB)