(19)

(11)

EP 1 084 135 A1

(12)

(43) Date of publication: 21.03.2001 Bulletin 2001/12 (21) Application number: 99955474.4 (22) Date of filing: 27.05.1999

(51) International Patent Classification (IPC)7: C07H 21/04, C12N 5/00, C12N 15/00, C07K 14/00, A61K 48/00 (86) International application number: PCT/US9911/757 (87) International publication number: WO 9964/435 (16.12.1999 Gazette 1999/50)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (30) Priority: 10.06.1998 US 95627 (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: CHEN, Zunxuan Blue Bell, PA 19422 (US) FREDRICKSON, Todd North Wales, PA 19454 (US) HU, Erding Audubon, PA 19403 (US) (74) Representative: Crump, Julian Richard John  FJ Cleveland,40-43 Chancery Lane London WC2A 1JQ London WC2A 1JQ (GB)