(19)

(11)

EP 1 084 142 A1

(12)

(43) Date of publication: 21.03.2001 Bulletin 2001/12 (21) Application number: 99955477.7 (22) Date of filing: 01.06.1999

(51) International Patent Classification (IPC)7: C07K 14/435, C12N 5/10, C12N 15/12, G01N 33/53 (86) International application number: PCT/US9912/123 (87) International publication number: WO 9964/452 (16.12.1999 Gazette 1999/50)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (30) Priority: 11.06.1998 US 96031 (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventor: ELSHOURBAGY, Nabil, A. West Chester, PA 19380 (US) (74) Representative: Crump, Julian Richard John et al FJ Cleveland,40-43 Chancery Lane London WC2A 1JQ London WC2A 1JQ (GB)