(19)

(11)

EP 1 084 242 A2

(12)

(88) Date of publication A3: 27.04.2000 (43) Date of publication: 21.03.2001 Bulletin 2001/12 (21) Application number: 99929185.9 (22) Date of filing: 10.06.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/435, C07K 14/47, C12N 5/10, C12N 15/62, C07K 16/18, C12Q 1/68, G01N 33/50, G01N 33/563, A61K 38/17 (86) International application number: PCT/EP9904/043 (87) International publication number: WO 9964/586 (16.12.1999 Gazette 1999/50)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 11.06.1998 GB 9812660 24.09.1998 GB 9820816 (71) Applicant: Devgen N.V. 9052 Zwijnaarde (BE)	(72) Inventors: SMITS, ElkeDevgen n.v. B-9052 Zwijnaarde (BE) VAN CRIEKINGE, Wim, Maria, Rene B-2500 Kontich (BE) BOGAERT, Thierry, Andre, Oliver, Eddy B-8500 Kortrijk (BE) (74) Representative: Baldock, Sharon Claire et al BOULT WADE TENNANT,Verulam Gardens70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)