(19)

(11)

EP 1 084 249 A2

(12)

(88) Date of publication A3: 29.12.1999 (43) Date of publication: 21.03.2001 Bulletin 2001/12 (21) Application number: 99920859.8 (22) Date of filing: 07.05.1999

(51) International Patent Classification (IPC)7: C12N 15/29, C07K 14/415, C12N 5/10, A01H 5/00, C07K 16/16 (86) International application number: PCT/EP9903/158 (87) International publication number: WO 9958/681 (18.11.1999 Gazette 1999/46)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 08.05.1998 ES 9800975 11.05.1998 ES 9800981 (71) Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS E-28006 Madrid (ES)	(72) Inventors: GUTIERREZ-ARMENTA, Crisanto E-28049 Madrid (ES) XIE, Qi E-28 049 Madrid (ES) RAMIREZ PARRA, Elena E-28049 Madrid (ES) (74) Representative: Dolan, Anthony Patrick  BTG International Ltd.,10 Fleet Place,Limeburner Lane London EC4M 7SB London EC4M 7SB (GB)