(19)

(11)

EP 1 085 886 A1

(12)

(43) Date of publication: 28.03.2001 Bulletin 2001/13 (21) Application number: 99931068.3 (22) Date of filing: 10.06.1999

(51) International Patent Classification (IPC)7: A61K 35/78 (86) International application number: PCT/EP9904/098 (87) International publication number: WO 9964/028 (16.12.1999 Gazette 1999/50)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 11.06.1998 US 96869 11.06.1998 US 89126 P (71) Applicant: SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES S.A.S. 75016 Paris (FR)	(72) Inventors: CHANDRASEKARAN, Krish Gaithersburg, MD 20879 (US) DRIEU, Katy F-75015 Paris (FR) (74) Representative: Lunt, Mark George Francis  Harrison Goddard Foote,Fountain Precinct,Leopold Street Sheffield S1 2QD Sheffield S1 2QD (GB)