(19)

(11)

EP 1 085 903 A1

(12)

(43) Date of publication: 28.03.2001 Bulletin 2001/13 (21) Application number: 99930430.6 (22) Date of filing: 18.06.1999

(51) International Patent Classification (IPC)7: A61K 39/00, C07K 1/00, C12Q 1/00, C12Q 1/68, G01N 33/53 (86) International application number: PCT/US9913/858 (87) International publication number: WO 9965/520 (23.12.1999 Gazette 1999/51)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 19.06.1998 US 89950 P (71) Applicant: The University of Virginia Patent Foundation Charlottesville, VA 22903 (US)	(72) Inventors: HERR, John, C. Charlottesville, VA 22901 (US) COONROD, Scott, A. Charlottesville, VA 22903 (US) (74) Representative: Horner, Martin Grenville  Cruikshank & Fairweather19 Royal Exchange Square Glasgow G1 3AEScotland Glasgow G1 3AEScotland (GB)