(19)

(11)

EP 1 086 083 A1

(12)

(43) Date of publication: 28.03.2001 Bulletin 2001/13 (21) Application number: 99928614.9 (22) Date of filing: 11.06.1999

(51) International Patent Classification (IPC)7: C07D 215/14, C07D 261/08, C07D 207/12 (86) International application number: PCT/US9913/334 (87) International publication number: WO 9964/399 (16.12.1999 Gazette 1999/50)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL (30) Priority: 12.06.1998 US 89056 P (71) Applicants: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US) SMITHKLINE BEECHAM PLC Brentford,Middlesex TW8 9EP (GB)	(72) Inventors: FENWICK, Ashley, E. Harlow,Essex CM19 5AD (GB) GRIBBLE, Andrew, D. Harlow,Essex CM19 5AD (GB) MARQUIS, Robert, W., Jr. St. Davids, PA 19087 (US) WITHERINGTON, Jason Harlow,Essex CM19 5AD (GB) (74) Representative: Rutter, Keith, Dr. et al SmithKline Beecham plcCorporate Intellectual Property,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)