(19)
(11) EP 1 086 116 A1

(12)

(43) Date of publication:
28.03.2001 Bulletin 2001/13

(21) Application number: 99923263.0

(22) Date of filing: 20.05.1999
(51) International Patent Classification (IPC)7C07H 21/04, A61K 48/00
(86) International application number:
PCT/US9911/214
(87) International publication number:
WO 9960/010 (25.11.1999 Gazette 1999/47)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 21.05.1998 US 83585

(71) Applicant: ISIS PHARMACEUTICALS, INC.
Carlsbad, CA 92008 (US)

(72) Inventors:
  • BENNETT, Clarence, Frank
    Carlsbad, CA 92009 (US)
  • ECKER, David, J.
    Encinitas, CA 92024 (US)
  • COOK, Phillip, Dan
    Fallbrook, CA 92028 (US)

(74) Representative: Hallybone, Huw George 
CARPMAELS AND RANSFORD43 Bloomsbury Square
London WC1A 2RA
London WC1A 2RA (GB)

   


(54) COMPOSITIONS AND METHODS FOR THE PULMONARY DELIVERY OF NUCLEIC ACIDS