(19)

(11)

EP 1 086 127 A1

(12)

(43) Date of publication: 28.03.2001 Bulletin 2001/13 (21) Application number: 99950345.1 (22) Date of filing: 10.05.1999

(51) International Patent Classification (IPC)7: C07K 14/21, C12N 15/31, C12N 15/62, C12N 15/63, C07K 16/12, A61K 39/02 (86) International application number: PCT/EP9903/262 (87) International publication number: WO 9958/562 (18.11.1999 Gazette 1999/46)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: SI (30) Priority: 12.05.1998 GB 9810193 (71) Applicant: SmithKline Beecham Biologicals s.a. 1330 Rixensart (BE)	(72) Inventor: THONNARD, Joelle,SmithKline Beecham Bio. S.A. 1330 Rixensart (BE) (74) Representative: Mallalieu, Catherine Louise  D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)