(19)

(11)

EP 1 086 131 A1

(12)

(43) Date of publication: 28.03.2001 Bulletin 2001/13 (21) Application number: 99931793.6 (22) Date of filing: 11.06.1999

(51) International Patent Classification (IPC)7: C07K 14/655, C07D 233/64, A61K 31/415, A61K 38/31 (86) International application number: PCT/US9913/304 (87) International publication number: WO 9965/942 (23.12.1999 Gazette 1999/51)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 16.06.1998 US 98181 16.06.1998 US 89503 P (71) Applicant: SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES S.A.S. 75016 Paris (FR)	(72) Inventor: GORDON, Thomas, D. Medway, MA 02053 (US) (74) Representative: Lunt, Mark George Francis et al Harrison Goddard Foote,Fountain Precinct,Leopold Street Sheffield S1 2QD Sheffield S1 2QD (GB)