(19)

(11)

EP 1 086 228 A1

(12)

(43) Date of publication: 28.03.2001 Bulletin 2001/13 (21) Application number: 99927922.7 (22) Date of filing: 08.06.1999

(51) International Patent Classification (IPC)7: C12N 15/30, C07K 14/45, C12N 15/81, A61K 39/002, G01N 33/569 (86) International application number: PCT/EP9903/957 (87) International publication number: WO 9966/043 (23.12.1999 Gazette 1999/51)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL (30) Priority: 12.06.1998 GB 9812773 15.04.1999 GB 9908564 (71) Applicant: SMITHKLINE BEECHAM BIOLOGICALS S.A. 1330 Rixensart (BE)	(72) Inventors: BIEMANS, Ralph B-1330 Rixensart (BE) BOLLEN, Alex B-1400 Nivelles (BE) HAUMONT, Michele B-1400 Nivelles (BE) (74) Representative: Privett, Kathryn Louise et al SmithKline Beecham plc,Corporate Intellectual Property,Two New Horizons Court - 2/NHC/1,Great West Road Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)